Premier 15s champions Saracens will start their title defence towards Loughborough Lightning when the 2022-23 season begins on the weekend of 19-20 November.
First-round matches happen following the climax of the delayed Rugby World Cup on 12 November.
The 18-round marketing campaign concludes with the title decider on 24 June 2023.
Saracens beat Exeter Chiefs 43-21 to win their third Premier 15s championship at Sixways in June, with England ahead Marlie Packer scoring two tries.
Runners-up Exeter will host Gloucester-Hartpury on the opening weekend.
Sharks, who’ve been within the girls’s high tier since its formation in 2017, arrange a crowdfunding bid earlier this month to lift £50,000 for assist with “primary working prices required to compete within the league this season”.
Funds had been raised by a “mixture of crowdfunding, sponsorship and public help”.
The bid, which raised simply over £26,000, requested for assist to “hold girls’s elite rugby alive within the North East”.
Harlequins, beneath new head coach Amy Turner, will tackle the renamed College of Worcester Warriors, whereas Wasps journey to Bristol Bears.
The Allianz Cup additionally returns for a successive season.
The primary two rounds might be performed throughout the weekends of 17 September and 24 September earlier than a two-week break. Rounds three, 4 and 5 might be performed in the course of the World Cup.